Cadherin as a tumor suppressor
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چکیده
منابع مشابه
Cadherin as a tumor suppressor
C ancer cells become far more dangerous when they gain the ability to metastasize and colonize other parts of the body. But to start moving, the rogue cells have to break away from their neighbors. Walter Birchmeier (now at the Max-Delbrück-Center of Molecular Medicine in Berlin, Germany) and colleagues discovered how, showing that some cancer cells down-regulate a surface receptor that locks a...
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Objective(s): microRNA-29 (miR-29) family miRNAs have been mentioned as tumor suppressive genes in several human cancers. The purpose of this study was to investigate the function of miR-29a in nasopharyngeal carcinoma (NPC) cells. Materials and Methods: Human NPC cell line 5-8F was transfected with mimic, inhibitor or scrambled controls...
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Protein kinase C (PKC) has historically been considered an oncoprotein. This stems in large part from the discovery in the early 1980s that PKC is directly activated by tumor-promoting phorbol esters. Yet three decades of clinical trials using PKC inhibitors in cancer therapies not only failed, but in some cases worsened patient outcome. Why has targeting PKC in cancer eluded successful therapi...
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Targeted protein degradation by the ubiquitin-proteasome system (UPS) has an essential role in carcinogenesis and cancer cell survival. Thus, the search for proteasome inhibitors is of great interest as a potential anticancer therapy. Recent studies by the Ferbeyre group suggest that certain UPS-targeted proteins play a role not just in carcinogenesis, but also in cellular senescence. The limit...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2006
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1724fta2